Indiana State fell to Illinois in the series finale, 5-2, as the Sycamores were swept by the Illini.
ISU had plenty of chances to tally a few runs, but went 0-for-10 with runners on base.
Dane Giesler added a solo home run.
The Trees are now 12-12 on the year. They conclude their Big 10 tour on Tuesday at Purdue.