INDIANAPOLIS (AP) — Indiana’s health commissioner has tested positive for COVID-19, the second time she has been infected.

The state health department announced Wednesday that Dr. Kristina Box was isolating at home after getting the results of a rapid test she took on Tuesday.

Box sought the test after experiencing symptoms including muscle aches, chills, coughing and a sore throat.

Box has been Gov. Eric Holcomb’s top adviser throughout the COVID-19 pandemic.

She previously had a mild coronavirus infection in October 2020 before vaccinations were available.

The department says Box is fully vaccinated and received a booster dose in November.